
Cyproheptadine also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Cyproheptadine's ability to stimulate appetite. Cyproheptadine also has been used to counter vascular headaches, which many believe are caused by changes in serotonin activity, however it is unclear how Cyproheptadine exerts a beneficial effect on this condition. For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.

Take Periactin with or without food. You should drink an entire glass of water with your dose. You'll likely be directed to take each 4 mg tablet every 4 to 6 hours throughout the day.

Get a prescription from your doctor if he determines that Periactin can help relieve your cold or allergy symptoms. Periactin is available as a syrup for pediatric patients or patients that have difficulty swallowing tablets. It also comes in the form of 4 mg tablets.

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