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Concurrent use of promethazine with the dye used for myelography (x-rays of the spinal cord) can lower the threshold for seizures and thus increase the risk of seizures. Promethazine should be stopped at least 48 hours before myelography and not restarted until at least 24 hours after myelography.

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To be sure you get the correct dose of promethazine oral syrup, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one..

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PREGNANCY: There are no adequate studies of promethazine in pregnant women. Administration of promethazine within 2 weeks of delivery may affect platelet function in the newborn.

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